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Advantages of Shanghai Yetuo Freeze Drying Machine
There are various drying methods, such as sun drying, boiling drying, drying, spray drying and vacuum drying, but common drying methods are usually carried out at temperatures above 0 ℃ or higher. The products obtained from drying generally have problems of volume reduction and texture hardening. Most of the volatile components are lost, and some heat sensitive substances undergo denaturation and deactivation. Some substances even undergo oxidation. Therefore, there is a significant difference in the characteristics of the dried product compared to before drying. The freeze-drying method is basically carried out below 0 ℃, that is, in the frozen state of the product, and the analytical drying generally does not exceed 60 ℃. Under vacuum conditions, when water vapor sublimates directly, the drug remains in the frozen ice shelf, forming a sponge like porous structure. Therefore, its volume size remains almost unchanged after drying. Before reuse, simply add injection water and it will dissolve immediately.
Compared to conventional methods, the Shanghai Yetuo freeze-drying machine has the following advantages in freeze-drying:
*Many thermosensitive substances do not undergo denaturation or inactivation.
*When dried at low temperatures, the loss of some volatile components in the substance is minimal.
*During the freeze-drying process, the growth of microorganisms and the action of enzymes cannot be carried out, so the original characteristics can be maintained.
*Due to drying in a frozen state, the volume remains almost unchanged, maintaining the original structure and preventing concentration.
*Due to the presence of water in the material in the form of ice crystals after pre freezing, inorganic salts dissolved in water are evenly distributed throughout the material. During sublimation, dissolved substances in water precipitate, avoiding the phenomenon of surface hardening caused by inorganic salts carried by the migration of internal moisture to the surface in general drying methods.
*After drying, the substance is loose and porous, appearing sponge like. It dissolves quickly after adding water and almost immediately returns to its original shape.
*Due to the drying process being carried out under vacuum with very little oxygen, some easily oxidizable substances are protected.
*Drying can remove over 95% to 99% of moisture, allowing the dried product to be stored for a long time without deterioration.
*Due to the frozen state of the material and the low temperature, the temperature requirement for the heating source is not high. A heater at room temperature or low temperature can be used to meet the requirements. If the freezer and dryer are separated, the dryer does not need to be insulated and there will not be a lot of heat loss, so the utilization of thermal energy is very economical. Select the type of freeze-drying machine based on its intended use: 1. Laboratory type. 2. Pilot type. 3 production type.
Below, I will introduce various types of freeze-drying machines for different purposes.
Shanghai Yetuo Laboratory type freeze dryer. The laboratory type freeze dryer has a small volume and comes in both desktop and vertical versions. Both desktop and vertical models are available in regular, cover type, and multi manifold type. The mainframe of a desktop freeze dryer has a relatively small volume and a small freeze-drying area, and the temperature of the cold trap is generally -50 degrees. Most use transparent bell shaped acrylic drums, allowing for observation of the material in the tray. Both pre freezing and drying of materials require relocation, and there is no temperature control function. Strictly speaking, it is not a complete freeze-drying machine. Due to the limited internal space of desktop computers, this type of machine cannot achieve a pre freezing temperature of -80 degrees. The vertical freeze dryer can be made into -80 pre freeze due to its large internal space. And due to the large internal space, it has good heat dissipation. This slows down the aging of compressors, control circuits, and other components. I suggest purchasing a vertical freeze dryer.
Shanghai Yetuo pilot freeze-drying machine. There are generally two types of pilot freeze-drying machines in China. One is a heating system that uses electric heating as the heating medium. One is a system using silicone oil as the heating medium. Visually, there are both square and circular cabins available, with circular cabins currently being largely phased out in China. Because the circular warehouse cannot be used for silicone oil heating, and the freeze-drying area is also not large. Let's take the cabin freeze dryer as an example to discuss electric heating and silicone oil heating. The shelf refrigeration of the electric heating freeze dryer comes directly from the evaporation end of the compressor. Rapid cooling. Low temperature. During the heating and warming process. Due to the rapid cooling, there is a conflict between cooling and heating, resulting in uneven temperature control. The temperature error is relatively large. For example, the shelf should be controlled at -20 degrees. When the refrigeration end is turned on, it is possible for the temperature to drop to -30 degrees instantly. Then slowly raise it to -20 degrees through the heating plate. Electric heating heats up quickly, causing sudden cooling and heating. Generally, temperature sensitive materials can cause melting or collapse. Some drugs even become inactive. So I suggest that for materials that are generally sensitive to temperature, electric heating freeze dryers are not recommended. Although it's cheaper. But the performance is relatively poor. Compared to electric heating, silicone oil freeze-drying machines are slightly more expensive in terms of cost. Performance wins! The freeze dryer with silicone oil as the medium is very reliable for both cooling and heating. The temperature can be controlled within 1 degree. It will not cause damage to the material. A real freeze dryer should use silicone oil as the heat transfer medium!
Shanghai Yetuo Production Freeze Drying Machine. The production type freeze-drying machine is relatively expensive in cost and has a high operating cost. Generally adopted by large enterprises.
